• High-density cultivation of terrestrial Nostoc strains leads to reprogramming of secondary metabolome 

      Guljamow, Arthur; Kreische, Marco; Ishida, Keishi; Liaimer, Anton; Altermark, Bjørn; Bähr, Lars; Hertweck, Christian; Dittmann, Elke (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-22)
      Terrestrial symbiotic cyanobacteria of the genus <i>Nostoc</i> exhibit a large potential for the production of bioactive natural products of the nonribosomal peptide, polyketide, and ribosomal peptide classes, and yet most of the biosynthetic gene clusters are silent under conventional cultivation conditions. In the present study, we utilized a high-density cultivation approach recently developed ...